Assignment Task
Cris Cerebrale – CNS Diseases Case Study 2021
Ischaemic stroke affects a growing number of people each year and is expected to
continue to rise as our population ages. As ischaemic stroke frequently results in
significant morbidity and mortality there remains a need to find ways to treat stroke
injury. Despite extensive understanding of the mechanisms involved in cellular death
following ischaemic injury there are still few therapeutic strategies available clinically.
Report topic: Discuss the potential for targeting the ischaemic cascade for
therapeutic advantage. You must choose 1 target of the ischaemic cascade and
describe 3 drugs at least 2 of which have made it to human trials. You should
consider the potential targets that may be advantageous in treating ischaemic stroke
as well as any existing data showing trials of agents interacting with this cascade
(successful or otherwise). What problems have been encountered and why is it that
so few of these drugs have been successful in trials? What does this mean for the
future of stroke therapeutics?
Case reports
Each student will prepare an individual report (750-1000 words). Your report must be prepared individually, written in your own words and be properly referenced in author-date style. We expect you will use a number of references in preparation of the report. You are welcome to use the reference given in the notes but are expected to add at least three more references to support your report. References to Web sites are generally NOT accepted. Please note that it is preferable to use the material that is the form of reports that are able to be referenced more readily than websites. Any material that has no print version is to be referenced in a similar manner to other references i.e. in the text an author and date, with full details, including URL and date of access in the reference list Students are encouraged to include diagrams to explain concepts covered and to be concise. Your report needs to include a discussion and explanation not just a list of facts.
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